Adenosina desaminasa en el diagnóstico molecular de pacientes con pleuritis tuberculosa y su relación con la respuesta inmunológica
Palabras clave:
Pleuritis tuberculosa, tuberculosis pleural, derrame pleural tuberculoso, adenosina desaminasa, anergia.Resumen
Se realizo una revisión sistemática, en donde se evidencio un análisis acerca de
la utilidad de la adenosina desaminasa desde la interpretación de sus puntos de
corte, la sensibilidad, la especificidad y los valores predictivos. Con el fin de llegar
a un relacionamiento de los contextos de tuberculosis pleural con la variación de los
niveles de adenosina desaminasa y la anergia desde una interpretación fisiopatología
e inmunológica. Para una compresión del papel de esta enzima en el diagnóstico e
inmunoterapia en relación con Mycobacterium tuberculosis, en donde la anergia es
fundamental.de los pacientes.
Citas
Global tuberculosis report 2021 [Internet]. Who.int. [citado 2022 Mar 19].
Shaw JA, Diacon AH, Koegelenberg CFN. Tuberculous pleural effusion. Respirology [Internet]. 2019;24(10):962–71.
Shaw JA, Irusen EM, Diacon AH, Koegelenberg CF. Pleural Tuberculosis: A concise clinical review. Clin Respir J [Internet]. 2018;12(5):1779–86.
Lo Cascio CM, Kaul V, Dhooria S, Agrawal A, Chaddha U. Diagnosis of tuberculous pleural effusions: A review. Respir Med [Internet]. 2021;188(106607):106607.
Vizcaíno-Salazar GJ. Importancia del cálculo de la sensibilidad, la especificidad y otros parámetros estadísticos en el uso de las pruebas de diagnóstico clínico y de laboratorio. Med Lab [Internet]. 2017 [citado 2022 Mar 19];23(7–8):365–86.
Kim H-J, Ryu S, Choi SH, Seo H, Yoo SS, Lee SY, et al. Comparison of biochemical parameters and chemokine levels in pleural fluid between patients with anergic and non-anergic tuberculous pleural effusion. Tuberculosis (Edinb) [Internet]. 2020;123(101940):101940. Disponible en: https://www.sciencedirect.com/science/article/pii/S1472979220301074
Vass G, Horváth I. Adenosine and adenosine receptors in the pathomechanism and treatment of respiratory diseases. Curr Med Chem [Internet]. 2008 [citado 2022 Mar 19];15(9):917–22. Available from: https://www.eurekaselect.com/article/11660
Novikov D. Allergy -- hypersensitivity with hyperreactivity [Internet]. Authorea Preprints. 2020 [citado 2022 Mar 19].
Antonangelo L, Faria CS, Sales RK. Tuberculous pleural effusion: diagnosis & management. Expert Rev Respir Med [Internet]. 2019;13(8):747–59.
Boggs ZH, Heysell S, Eby J, Arnold C. Adenosine deaminase negative pleural tuberculosis: a case report. BMC Infect Dis [Internet]. 2021;21(1).
Kim SB, Shin B, Lee J-H, Lee SJ, Lee MK, Lee W-Y, et al. Pleural fluid ADA activity in tuberculous pleurisy can be low in elderly, critically ill patients with multi-organ failure. BMC Pulm Med [Internet]. 2020;20(1):13.
Aggarwal AN, Agarwal R, Sehgal IS, Dhooria S. Adenosine deaminase for diagnosis of tuberculous pleural effusion: A systematic review and meta-analysis. PLoS One [Internet]. 2019;14(3):e0213728.
Kouméka PP, Ouldittou I, Fikri O, Saidi I, Ait Batahar S, Amro L. Facteurs prédictifs et biomarqueurs de la pleurésie exsudative lymphocytaire tuberculeuse. Rev Mal Respir [Internet]. 2021;38(3):231–9.
Fielli M, Gonzalez A, Heres M, Carreño Saavedra R, Asquineyer Y, Benitez R, et al. Determinación del valor de adenosina deaminasa en tuberculosis pleural [Internet]. Medicinabuenosaires.com.[citadoel 3 demarzode 2022].
López-Medrano R, Fuster Foz C, Burgos Asurmendi I, Raya Fernández C. Uso de adenosina deaminasa como indicador para seleccionar líquidos pleurales para cultivo y/o técnicas moleculares para detección de micobacterias. Enferm Infecc Microbiol Clin [Internet]. 2019;37(3):208–9.
Zhang M, Li D, Hu Z-D, Huang Y-L. The diagnostic utility of pleural markers for tuberculosis pleural effusion. Ann Transl Med [Internet]. 2020 [citado el 3 de marzo de 2022];8(9):607. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32566633/
He J, Zhang R, Shen Y, Wan C, Zeng N, Qin J, et al. Diagnostic accuracy of interleukin-22 and adenosine deaminase for tuberculous pleural effusions. Curr Res Transl Med [Internet]. 2018;66(4):103–6.
Santos AP, Corrêa R da S, Ribeiro-Alves M, Soares da Silva ACO, Mafort TT, Leung J, et al. Application of Venn’s diagram in the diagnosis of pleural tuberculosis using IFN-γ, IP-10 and adenosine deaminase. PLoS One [Internet]. 2018;13(8):e0202481.
Yang X, Zhang J, Liang Q, Pan L, Duan H, Yang Y, et al. Use of T-SPOT.TB for the diagnosis of unconventional pleural tuberculosis is superior to ADA in high prevalence areas: a prospective analysis of 601 cases. BMC Infect Dis [Internet]. 2021;21(1).
Feng M, Sun F, Wang F, Cao G. The diagnostic effect of sequential detection of ADA screening and T-SPOT assay in pleural effusion patients. Artif Cells Nanomed Biotechnol [Internet]. 2019;47(1):3272–7.
Fenhua J, Daohui W, Hui L, Xiaodong X, Wen H. Diagnostic value of combined pleural interleukin-33, adenosine deaminase and peripheral blood tuberculosis T cell spot detection TB for tuberculous pleurisy. BMC Infect Dis [Internet]. 2021 [citado el 3 de marzo de 2022];21(1):861
Blakiston M, Chiu W, Wong C, Morpeth S, Taylor S. Diagnostic performance of pleural fluid adenosine deaminase for tuberculous pleural effusion in a low incidence setting. J Clin Microbiol [Internet]. 2018 [citado el 3 de marzo de 2022];56(8).
Beukes A, Shaw JA, Diacon AH, Irusen EM, Koegelenberg CFN. The utility of pleural fluid lactate dehydrogenase to adenosine deaminase ratio in pleural tuberculosis. Respiration [Internet]. 2021;100(1):59-63.Disponible en: http://dx.doi.org/10.1159/000509555
Teke T. New biomarkers used in the diagnosis of tuberculosis-related pleural effusions. J Pediatr Infect Dis [Internet]. 2020;15(03):113-7.
Chakraborty A, Ramaswamy S, Shivananjiah AJ, Puttaswamy RB, Chikkavenkatappa N. The role of genexpert in the diagnosis of tubercular pleural effusion in India. Adv Respir Med [Internet]. 2019 [citado el 3 de marzo de 2022];87(5):276-80.
Solari L, Soto A, Van der Stuyft P. Development of a clinical prediction rule for the diagnosis of pleural tuberculosis in Peru. Int J Infect Dis [Internet]. 2018; 69:103-7.
Garcia-Zamalloa A, Vicente D, Arnay R, Arrospide A, Taboada J, Castilla-Rodriguez I, et al. Diagnostic accuracy of adenosine deaminase for pleural tuberculosis in a low prevalence setting: A machine learning approach within a 7-year prospective multi-center study. PLoS One [Internet]. 2021;16(11):e0259203.
Petborom P, Dechates B, Muangnoi P. Differentiating tuberculous pleuritis from other exudative lymphocytic pleural effusions. Ann Palliat Med [Internet]. 2020;9(5):2508-15. Disponible en: http://dx.doi.org/10.21037/apm-19-394
Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V. Comparative accuracy of pleural fluid unstimulated interferon-gamma and adenosine deaminase for diagnosing pleural tuberculosis: A systematic review and meta-analysis. PLoS One [Internet]. 2021;16(6):e0253525.
Zhang J, Chen Y, He G, Jiang X, Chen P, Ouyang J. Differential diagnosis of tuberculous and malignant pleural effusions: comparison of the Th1/Th2 cytokine panel, tumor marker panel and chemistry panel. Scand J Clin Lab Invest [Internet]. 2020;80(4):265-70.
Tang Y, Zhang J, Huang H, He X, Zhang J, Ou M, et al. Pleural IFN-γ release assay combined with biomarkers distinguished effectively tuberculosis from malignant pleural effusion. BMC Infect Dis [Internet]. 2019;19(1):55.
Ren Z-H, Xu L. Biomarkers of distinguishing neutrophil-predominant tuberculous pleural effusion from parapneumonic pleural effusion. Am J Med Sci [Internet]. 2021;361(4):469-78.
Qiu Y, Zeng W, Zhang H, Zhong X, Tang S, Zhang J. Comparison of pleural effusion features and biomarkers between talaromycosis and tuberculosis in non-human immunodeficiency virus-infected patients. BMC Infect Dis [Internet]. 2019;19(1):745.
Shimoda M, Tanaka Y, Morimoto K, Shimoda K, Takemura T, Oka T, et al. Sjogren’s syndrome with pleural effusion: Difficult to distinguish from tuberculous pleurisy because of a high adenosine deaminase level. Intern Med [Internet]. 2022;61(4):517-21.
Palma RM, Bielsa S, Esquerda A, Martínez-Alonso M, Porcel JM. Eficacia diagnóstica de la adenosina desaminasa en líquido pleural para diagnosticar tuberculosis. Metaanálisis de estudios españoles. Arch Bronconeumol [Internet]. 2019;55(1):23-30.
Jiang C-G, Wang W, Zhou Q, Wu X-Z, Wang X-J, Wang Z, et al. Influence of age on the diagnostic accuracy of soluble biomarkers for tuberculous pleural effusion: a post hoc analysis. BMC Pulm Med [Internet]. 2020;20(1):178.
Korczynski P, Klimiuk J, Safianowska A, Krenke R. Impact of age on the diagnostic yield of four different biomarkers of tuberculous pleural effusion. Tuberculosis (Edinb) [Internet]. 2019 [citado el 3 de marzo de 2022];114:24-9.
Bayhan GI, Sayir F, Tanir G, Tuncer O. Pediatric pleural tuberculosis. Int J Mycobacteriol [Internet]. 2018;7(3):261-4.
Rodriguez R. Tuberculosis pleural en paciente pediátrico: reporte de un caso y revisión de la literatura pleural. Neumol Pediatr [Internet]. 2018;13(1):29-31.
Vieira JL, Foschiera L, Ferreira ICS, Chakr VCBG. Performance of the quantification of adenosine deaminase and determination of the lactate dehydrogenase/adenosine deaminase ratio for the diagnosis of pleural tuberculosis in children and adolescents. J Bras Pneumol [Internet]. 2021;47(2):e20200558.
da Costa FM, Vasconcelos LP, Lau Rodriguez ELC, Costa EAD, Cerezoli MT. Bilateral chylothorax secondary to tuberculosis in a pregnant patient: A case report. En: D47 TUBERCULOSIS:CASE REPORTS.American Thoracic Society; 2018.6948.
Baysak A, Ece G, Emre J, Oz A, Sahin E. A rare cause of pleurisy in pregnancy: Tuberculosis. Int Med J Sifa Univ [Internet]. 2014 [citado el 3 de marzo de 2022];1(1):9.
Afaq T. 1245: Tuberculous pleural effusion in a pregnant female. Crit Care Med [Internet]. 2012; 40:1-328.
Carmen Pérez-Aguilar M, Goncalves L, Ibarra A, Bonfante-Cabarcas R. Adenosin deaminasa como molécula coestimuladora y marcador de inmunidad celular. Invest Clin [Internet]. 2010;51(4):561-71.
Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Chu WC, Xu X, et al. BCG-induced trained immunity in healthy individuals: The effect of plasma muramyl dipeptide concentrations. J Immunol Res [Internet]. 2020; 2020:5812743.
Boussiotis VA, Tsai EY, Yunis EJ, Thim S, Delgado JC, Dascher CC, et al. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest [Internet]. 2000 [citado el 31 de marzo de 2022];105(9):1317–25.
Han X-F, Han C, Jin F, Wang J-L, Wang M-S. Factors associated with negative pleural adenosine deaminase results in the diagnosis of childhood pleural tuberculosis. BMC Infect Dis [Internet]. 2021;21(1).
Yan L, Cui H, Xiao H, Zhang Q. Anergic pulmonary tuberculosis is associated with contraction of the Vd2+T cell population, apoptosis and enhanced inhibitory cytokine production.PLoSOne[Internet].2013;8(8):71245.
Iñiguez RT. Use of live attenuated mycobacteria as treatment against asthma and their ability to induce trained immunity. Universidad de Zaragoza; 2019.
Mulder WJM, Ochando J, Joosten LAB, Fayad ZA, Netea MG. Therapeutic targeting of trained immunity. Nat Rev Drug Discov [Internet]. 2019;18(7):553-66.
Park JE, Kim H-J, Choi SH, Lee YH, Seo H, Yoo SS, et al. The role of CECR1 in the immune-modulatory effects of butyrate and correlation between ADA2 and M1/M2 chemokines in tuberculous pleural effusion.Int Immunopharmacol[Internet].2021;96(107635).
Li Q, Li L, Liu Y, Fu X, Qiao D, Wang H, et al. Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors. Cell Mol Immunol [Internet]. 2011 [citado el 28 de marzo de 2022];8(2):172–80.
von Hertzen L, Klaukka T, Mattila H, Haahtela T. Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions. Journal of Allergy and Clinical Immunology [Internet]. 1999 [cited 2022 Mar 28];104(6):1211–4.
OMS. Treatment of tuberculosis: guidelines. 4a ed. Genève, Switzerland: World Health Organization; 2010.
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