Una revisión sistemática de la literatura sobre la enfermedad tiroidea oculardermatolaringologica
Palabras clave:
Enfermedad tiroidea, exoftalmos, enoftalmos, colágeno, hipertiroidismo e hipotiroidismo.Resumen
La enfermedad tiroidea subclínica (ETS) es una condición asintomática de alta
prevalencia que incluye el hipertiroidismo subclínico (HiperSC) y el hipotiroidismo
subclínico (HipoSC). Ambas formas no tienen síntomas ni signos específicos y
solamente pueden ser detectados mediante exámenes hormonales. Las causas más
frecuentes de HiperSC son la enfermedad de Graves y el bocio multinodular.
De HipoSC la causa más frecuente es la tiroiditis crónica autoinmune (enfermedad
de Hashimoto). El criterio diagnóstico para HiperSC es TSH sérica de ≤0.4mU/L y
valores normales deT4 total o libre. El criterio diagnóstico para HipoSC es TSH sérica
de 4.5-10mU/L junto con valores normales de T4 total o libre. Ambas se consideran
más severas cuando los valores de TSH se alejan del valor normal: <0.1mU/L HiperSC
y >10mU/L en HipoSC.
En la ETS las alteraciones cardiovasculares son frecuentes, pero de distinta índole,
así en el HiperSC hay mayor riesgo de arritmias supraventriculares mientras en el
HipoSC hay un riesgo aumentado de dislipidemia y ateroesclerosis. En este artículo
se analizan los aspectos diagnósticos de la ETS, sus complicaciones y se propone un
plan de manejo desde una perspectiva clínica. (1).
Durante el actual apartado se expondrán las afecciones patológicas que
pueden ocasionar las alteraciones de la tiroides a nivel dermatológico, ocular y
otorrinolaringológico, en este último caso particular hace referencia a las lesiones
en gran mayoría asociadas con cáncer intervenido de la tiroides. Así como el papel
de la ayuda diagnostica en el abordaje del paciente.
Citas
Cooper D.S, Biondi B. Subclinical thyroid disease. Lancet. 2020;379:1142-1154.
Hollowell J., Staehling NW, Flanders WD, et al. Serum TSH, T4 and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III).J Clin Endocrinol Metab. 2020;87:489-499.
Vadiveloo T, Donnan PT, Cochrane L, Lee GP The thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism. J Clin Endocrinol. 2020;96:59-61.
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2020;160:526-534.
Cappola A, Fried LP, Arnold AM, et al. Thyroid status, cardiovascular risk, and mortality in older adults. JAMA. 2020;295:1033-1041.
Panatalone KM, et al. Approach to a low TSH level: patience is a virtue. Cleveland Clinic Journal of Medicine. 2020;77:803-811.
Martino E, Bartalena L, Bogazzi F, Braverman LE, et al. The effects of amiodarona on the thyroid. Endocrine Reviews. 2020;22:240-254.
Flynn RW, Bonelle SR, Jung RT, Mac Donald TM, Morris AD, Leese GP. Serum thyroid-stimulating hormone concentration and morbility from cardiovascular disease and fractures in patients on long-term thyroxine therapy. J Clin Endocrinol Metab. 2020;95:186-193.
Sgarbi JA, Villaca F, Garbelini B, Villar HE, Romaldini JH. The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism on clinical and heart abnormalities. J Clin Endocrinol Metab 2020;1672-77.
Bondi B, Palmieri E, Fazio S, et al. Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and midled-aged patients. J Clin Endocrinol Metab. 2020;85:4701-4705
Völzke H, Robinson DM, Schminke U, et al. Thyroid function and carotid wall thickness. J Clin Endocrinol Metab. 2020;89:2145-2149
Dörr M, Empen K, Robinson DM, Wallaschofski H, Felix SB, Völzke H. The association of thyroid function with carotid plaque burden and strokes in a population-based simple from a previous iodine-deficient área. Eur J Endocrinol. 2020;159:145-152.
Tseng FY, Lin CC, Lee LT, Li TC, Sung PK, Huang KC. Subclinical hypothyroidism is associated with increased risks for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol. 2020;60:730-737.
Bauer DC, Ettinger B, Nevitt MC, Stone KL, et al. Study of Osteoporotic Fractures Research Group. Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann InternMed. 2020;134:561-568.
Somwaru LL, Rariy CM, Arnold AM, Cappola AR The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study. JCEM. 2020;97:1962-1969.
Pearce EN Update in lipid alterations in subclinical hypothyroidism. Endocrinol Metab. 2020;97:326-333.
Kiss EG, Jakab EG, Edes IL. Thyroid hormone induced alteration in phospholambam protein expression: Regulatory effects on sarcoplasmic reticulum Ca2+ trasport and myocardial relaxation. Circ. Res. 2020;75:245-251.
Mansourian AR. Metabolic pathways of tetraiodothyronine (T4) and triidothyronine (T3) production by thyroid gland: A review of articles.Pak. J. Biol. Sci.2020;14:
Ojamaa K, Klein I, Sabet A, Steinberg SF. Metabolism. 2020;49:275-279.
Ojamaa K, Lowenstein E, Klein I and Sellke FW. Anesthesia Analgesia. 1997;85:734-738.6
Park KW, Dai HB, Ojamaa K, Lowenstein E, Klein I, Sellke FW. Anesthesia Analgesia. 2020;85:734-738.
Lervasi G, Pingitore A, Landi P, Raciti M., Ripoli A. Low-T3 syndrome: A strong prognostic predictor of death in patients with heart disease. Circulation. 2020;107:708-713.
Hak AE, Pols HAP, Visser TJ, Drexhage H.A, Hofman A, Witteman JCM. Subclinical hypothyroidism is an independent risk factor for aterosclerosis and myocardial infarction in elderly women. The Rotterdam study. Ann Intern. Med. 2019;132:270-278.
Imaizumi M, Akahoshi M, Ichimaru S, Nakashima E, Hida A. Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism. J Clin Endocrinol Metab. 2019;89:3365-3370.
Kventny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low grade inflamation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years.Clin Endocrinol. 2019;61:232-238.
Volzke HC, Schwahn C, Wallaschfski H, Dorr M. The association of thyroid dysfunction with all cause and circulatory mortality: Is there a causal relationship? J Clin Endocrinol Metab. 2019;92:2421-2429.
Dorr M, Voolzke H. Minerva Cardiovascular morbidity and mortality in thyroid dysfunction. Minerva Endocrinol. 2019;30:199-216.
Wartofsky L. Cardiovascular risk and subclinical hypothyroidism: Focus on lipids and new emerging risk factors. What is the evidence? Thyroid. 2019;17:1075-1084.
Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2019;29:76-131.
Duntas LH, Mantzou E, Koutras DA. Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism. Thyroid. 2019;12:1003-1007.
Bengel FM, Nekolla SG, Ibrahim T, Weniger C, Ziegler SL, Schwaiger M. Effect of thyroid hormones on cardiac function, geometry and oxidative metabolism assessed noninvasivaly by positrón emission tomography and magnetic resonance imaging. J Clin Endocrinol Metab. 2019;85:1822-1827.
Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guideliness for diagnosis and management. JAMA. 2019;291:228-238.
Medicare coverage of routine screening for thyroid dysfuntion. Washington, DC: Institute of Medicine. National Academies Press. 2019.
Ladenson P.W., Singer P.A., Ain K.B., et al. American thyroid association guidelines for detection of thyroid dysfuntion. Arch Intern Med. 2019;160:1573-1575.
Helfand M. US Preventive Services Task Force. Ann Intern Med. 2019;140:128-141.
Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI. Serum thyrotropin measurements in the community. Arch Intern Med. 2019;167:1533-1538.
Diez JJ, et al. Analysis of the natural course of subclinical hyperthyroidism. Am J Med Sci. 2019;337:225-232.
Vanderpump MP, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Wickham survey. Clin Endocrinol. 2019;43:55-68.
Díez JJ, et al. Spontaneous subclinical hypothyroidism in patients older than 55 years: analysis of natural course and risk factors for the development of overt thyroid failure. J Clin Endocinol Metab. 2019;89:4890-4897.
Parle JV, et al. Prevalence and follow-up of abnormal thyrotropin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrin (Oxf). 2019;34:77-83.
Pérez Moreiras JV, Coloma Bockos JE, Prada Sánchez MC. Orbitopatía tiroidea (fisiopatología, diagnóstico y tratamiento). Coloma Bockos Je, Prada Sánchez Mc. 2019.
Perez Moreiras JV, Prada Sanchez MC, Coloma Bockos J, Prats J, Adenis JP, Rodriguez Alvarez F, Perez Becerra E. Oftalmopatia distiroidea. Patología Orbitaria. Barcelona: Edika Med. 2019;2:949-1033.
Wiersinga WM, Bartalena L. Epidemiology and Prevention of Graves’ ophthalmopathy. Thyroid 2019;12:855-860.
Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997;84:223-243.
Perez Moreiras JV, Prada Sanchez MC, Coloma Bockos J. Oftalmopatia Distiroidea. Oftalmologia Practica 2019;16:24-58.
Kazim M, Goldberg RA, Smith TJ. Insights into pathogenesis of thyroid-associated orbitopathy: evolving rationale for therapy. Arch Ophthalmol 2019;120:380-386.
Rootman J, Dolman PJ. Thyroid Orbitopathy. In: Rootman J. Diseases of The Orbit. Philadelphia: Lippincott Williams & Wilkins 2019;169-212.
Facciani JM, Kazim M. Absence of seasonal variation in Graves disease. Ophthal Plast Reconstr Surg 2018;16:67-71.
Bartley GB, Fatourechi V, Kadrmas EF, Jacobsen SJ, Ilstrup DM, Garrity JA et al. The treatment of Graves’ ophthalmopathy in an incidence cohort. Am J Ophthalmol 2018;121:200-206.
Pfeilschifter J, Ziegler R. Smoking and endocrine ophthalmopathy: impact of smoking severity and current vs lifetime cigarette consumption. Clin Endocrinol (Oxf). 201845:477-481.
Kimball LE, Kulinskaya E, Brown B, Johnston C, Farid NR. Does smoking increase relapse rates in Graves’ disease? J Endocrinol Invest. 2018;25:152-157
Bahn RS. Thyrotropin receptor expression in orbital adipose/connective tissues from patients with thyroid-associated ophthalmopathy. Thyroid. 2018;12:193-195.
Alcázar Lázaro V, Aguilar Martínez A. Alteraciones dermatológicas asociadas a hipotiroidismo. Sección de Endocrinología, Hospital Severo Ochoa, Leganés, España,Servicio de Dermatología, Hospital Severo Ochoa, Leganés, España, 2018.
Pardal-Refoyo JL. Tiroidología y paratiroidología. Cirugía de tiroides y paratiroides. Rev ORL. Pino Rivero V, Pardo Romero G, Trinidad Ruíz G, García M, Alcaraz Fuentes M, Blasco Huelva A. Cirugía de la Glándula Tiroides, Revisión y Análisis de 500 Pacientes Consecutivos Intervenidos. 2018.
Mack WP, Stasior GO, Cao HJ, Stasior OG, Smith TJ. The effect of cigarette smoke constituents on the expression of HLA-DR in orbital fibroblasts derived from patients with Graves ophthalmopathy. Ophthal Plast Reconst Surg 1999;15:260-271.
Anderson DJ, Axel R. Molecular probes for the development and plasticity of neural crest derivates. Cell 12018;42:649-662.
Cockerham KP, Hidayat AA, Brown HG, Cockerham GC, Graner SR. Clinicopathologic evaluation of the Mueller muscle in thyroid-associated orbitopathy. Ophthal Plast Reconstr Surg 2018;18:11-17
Kikkawa DO, Pornpanich K, Cruz RC Jr, Levi L, Granet DB. Graded orbital decompression based on severity of proptosis. Ophthalmology 2018;109:1219-1224
Lacey B, Chang W, Rootman J. Nonthyroid causes of extraocular muscle disease. Surv Ophthalmol 2018;44:187-213.
Cabanis E, Bourgeois H, Iba-Zizen MT. Orbitopathies dysthyroidiennes. L’Imagirie en ophtalmologie. Societe Française D’Oftalmologie 2018;35:558-572
Nugent RA, Belkin RI, Neigel JM, Rootman J, Robertson WD, Spinelli J et al. Graves orbitopathy: correlation of CT and clinical findings. Radiology 2018; 177: 675-682]63.
Dolman P, Rootman J. Visa classification for Graves orbitopathy. In: Vancouver Orbital Symposium. Vancouver 2018;135-136.
Descargas
Publicado
Versiones
- 2025-11-12 (4)
- 2025-11-12 (3)
- 2025-08-13 (2)
- 2021-10-20 (1)
Cómo citar
Número
Sección
Licencia
Derechos de autor 2021 Scientific and Eduaction Medical Journal

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Atribución – No comercial – Compartir igual: Esta licencia permite a otros distribuir, remezclar, retocar, y crear a partir de tu obra de modo no comercial, siempre y cuando te den crédito y licencien sus nuevas creaciones bajo las mismas condiciones.
Attribution-NonCommercial-ShareAlike 4.0 International


